Erythrocyte survival is controlled by microRNA-142

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چکیده

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Erythrocyte survival is controlled by microRNA-142

Hematopoietic-specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-function allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resili...

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ژورنال

عنوان ژورنال: Haematologica

سال: 2016

ISSN: 0390-6078,1592-8721

DOI: 10.3324/haematol.2016.156109